Semitelechelic HPMA copolymers functionalized with triphenylphosphonium as drug carriers for membrane transduction and mitochondrial localization
J Callahan, J Kopeček - Biomacromolecules, 2006 - ACS Publications
… Mitochondria-targeting drug carriers could be used as effective vectors for anticancer drugs,
as well as other drugs, … , or other signal transduction factors localized in the mitochondria. …
as well as other drugs, … , or other signal transduction factors localized in the mitochondria. …
Novel HPMA copolymer-bound constructs for combined tumor and mitochondrial targeting
V Cuchelkar, P Kopečková… - Molecular …, 2008 - ACS Publications
… using triphenylphosphonium (TPP) ions as mitochondrial targeting agents for semitelechelic
HPMA copolymers. (… -based drug delivery systems, with degradation of the disulfide bond on …
HPMA copolymers. (… -based drug delivery systems, with degradation of the disulfide bond on …
Design of smart HPMA copolymer-based nanomedicines
… in drug delivery, the design, synthesis and evaluation of drug-… possessing 4 mol% of
moderately hydrophobic functional … protection (usually a semitelechelic hydrophilic polymer) is …
moderately hydrophobic functional … protection (usually a semitelechelic hydrophilic polymer) is …
Near-infrared light-triggered drug-delivery vehicle for mitochondria-targeted chemo-photothermal therapy
… to the inner mitochondrial membrane by anionic phospholipid … of the polyvalent
aptamer-functionalized mesoporous silica-… cells, with no particular mitochondrial localization. In …
aptamer-functionalized mesoporous silica-… cells, with no particular mitochondrial localization. In …
Polymer–drug conjugates: Origins, progress to date and future directions
J Kopeček - Advanced drug delivery reviews, 2013 - Elsevier
… we designed an HPMA copolymer–cyclopamine conjugate (P-… The single functional group
on ST-PEG provides the opportunity … First, a semitelechelic polymer is synthesized by RAFT …
on ST-PEG provides the opportunity … First, a semitelechelic polymer is synthesized by RAFT …
The Use of HPMA Copolymer Conjugates for the Intracellular Targeting of Anticancer Drugs
JD Callahan - 2017 - search.proquest.com
… to an HPMA-doxorubicin anticancer drug carrier. Monoclonal … Semitelechelic TPP-HPMA
copolymers were synthesized to … of TPP-functionalized semitelechelic HPMA copolymers ........…
copolymers were synthesized to … of TPP-functionalized semitelechelic HPMA copolymers ........…
Polymer-drug conjugates for anticancer drug delivery
… conjugates” by grafting semitelechelic HPMA copolymer onto star-… HPMA copolymers
functionalized to have either free carboxyl … HPMA-copolymer–triphenylphosphonium conjugate …
functionalized to have either free carboxyl … HPMA-copolymer–triphenylphosphonium conjugate …
[HTML][HTML] Two birds, one stone: dual targeting of the cancer cell surface and subcellular mitochondria by the galectin-3-binding peptide G3-C12
W Sun, L Li, L Li, Q Yang, Z Zhang… - Acta Pharmacologica …, 2017 - nature.com
… , G3-C12-HPMA-KLA disrupted the mitochondrial membrane, … The lipophilic
triphenylphosphonium (TPP) cation is a classic … HPMA copolymer conjugates containing different …
triphenylphosphonium (TPP) cation is a classic … HPMA copolymer conjugates containing different …
Multifunctional water-soluble polymers for drug delivery
H Pan, J Kopecek - Multifunctional pharmaceutical nanocarriers, 2008 - Springer
… Semitelechelic HPMA copolymers functionalized with triphenylphosphonium as drug carriers
for membrane transduction and mitochondrial localization. Biomacromolecules 7: 2347–…
for membrane transduction and mitochondrial localization. Biomacromolecules 7: 2347–…
Molybdenum trioxide nanoparticles with intrinsic sulfite oxidase activity
… group and triphenylphosphonium ion as targeting agent, … Here we demonstrate that surface
functionalized MoO 3 … cellular membrane and accumulate specifically at the mitochondria (…
functionalized MoO 3 … cellular membrane and accumulate specifically at the mitochondria (…